A deep-sea submersible filled with an international research crew lies disabled at the bottom of the Pacific after having been attacked by a massive shark previously thought to be extinct. With time running out, expert deep sea rescue diver Jonas Taylor (Jason Statham) is recruited by a visionary Chinese oceanographer (Winston Chao) to save the crew—and the ocean itself—from this unstoppable threat: a pre-historic 75-foot-long shark known as the Megalodon. Primatologist Davis (Dwayne Johnson) shares an unshakable bond with George, the extraordinarily intelligent, silverback gorilla who has been in his care since birth. When a greed-fueled corporation's genetic experiment goes awry, George and other animals across the country are mutated into aggressive super creatures that rampage the city.